Paroxysmal nocturnal haemoglobinuria. RI of renal cortical haemosiderosis in two patients, including one renal transplant
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چکیده
منابع مشابه
Paroxysmal nocturnal haemoglobinuria with renal, infective and immunological abnormalities.
Introduction Paroxysmal nocturnal haemoglobinuria (PNH) is a rare disease characterized by a membrane abnormality of red cells leading to episodic haemolysis. It has only occasionally been observed in the elderly (Sirchia and Lewis, 1975). The rarity of the disease, the insidious development of symptoms and variety of presentations mean that diagnosis may be incorrect or delayed (Polli et al., ...
متن کاملParoxysmal Nocturnal Haemoglobinuria
A Clinico-Pathological Conference held in the University of Bristol on the 6th November 1962 chairman: professor t. f. hewer Dr. Crow: This lady was 57 at the time of death and although her early history isi little scanty it seems likely that the disease which ultimately caused her death first presented around the age of 21. We have nothing like complete notes up to 1953, but even so her notes ...
متن کاملRenal transplantation for end-stage renal disease due to paroxysmal nocturnal haemoglobinuria.
Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by nocturnal haemoglobinuria, haemolytic anaemia, and thrombosis [ 1]. Most patients have anatomical and functional renal abnormalities, although renal function deterioration often remains unrecognized. The pathogenesis could be related to iron deposition or to repeated vascular thrombosis. The present case illustrates that renal trans...
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The complement system plays a central part in both innate and acquired immunity, but the contribution of complement activation to pathobiology is largely ancillary. An exception to the non-dominant role of complement in disease is the haemolytic anaemia of paroxysmal nocturnal haemoglobinuria (PNH). The intravascular haemolysis that is the clinical hallmark of PNH is a consequence of deficiency...
متن کاملSevere haemolysis and renal failure in a patient with paroxysmal nocturnal haemoglobinuria.
Transfusion of about 60 ml of ABO incompatible plasma in 4 units of pooled platelets precipitated severe haemolysis, unmasking the emergence of paroxysmal nocturnal haemoglobinuria (PNH), in a patient with aplastic anaemia. In vitro tests showed that her red cells were lysed by both ABO compatible and incompatible plasma from normal donors. The behaviour of this case and the in vitro results su...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1999
ISSN: 1460-2385
DOI: 10.1093/ndt/14.6.1586